CATH Domain 3ly6A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.260	Coagulation Factor XIII; Chain A, domain 2
	3.90.260.10	Transglutaminase-like

Domain Context

CATH Clusters

Superfamily	Transglutaminase-like
Functional Family	Protein-glutamine gamma-glutamyltransferase 2

Enzyme Information

2.3.2.13

Protein-glutamine gamma-glutamyltransferase.

based on mapping to UniProt P21980

A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).

-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

P21980

TGM2_HUMAN

Homo sapiens

Protein-glutamine gamma-glutamyltransferase 2

PDB Structure

PDB	3LY6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of human transglutaminase 2 in complex with adenosine triphosphate Han, B.G., Cho, J.W., Cho, Y.D., Jeong, K.C., Kim, S.Y., Lee, B.I. Int.J.Biol.Macromol.