CATH Domain 3l8vA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	3L8V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Williams, D.K., Chen, X.T., Tarby, C., Kaltenbach, R., Cai, Z.W., Tokarski, J.S., An, Y., Sack, J.S., Wautlet, B., Gullo-Brown, J., Henley, B.J., Jeyaseelan, R., Kellar, K., Manne, V., Trainor, G.L., Lombardo, L.J., Fargnoli, J., Borzilleri, R.M. Bioorg.Med.Chem.Lett.