CATH Domain 3kijA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.30	Glutaredoxin
	3.40.30.10	Glutaredoxin

Domain Context

CATH Clusters

Superfamily	Glutaredoxin
Functional Family	Glutathione peroxidase

Enzyme Information

1.11.1.9

Glutathione peroxidase.

based on mapping to UniProt Q8TED1

2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.

-!- Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 on phospholipids, can act as acceptor, but more slowly than H(2)O(2) (cf. EC 1.11.1.12).

UniProtKB Entries (1)

Q8TED1

GPX8_HUMAN

Homo sapiens

Probable glutathione peroxidase 8

PDB Structure

PDB	3KIJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Two Endoplasmic Reticulum PDI Peroxidases Increase the Efficiency of the Use of Peroxide during Disulfide Bond Formation. Nguyen, V.D., Saaranen, M.J., Karala, A.R., Lappi, A.K., Wang, L., Raykhel, I.B., Alanen, H.I., Salo, K.E., Wang, C.C., Ruddock, L.W. J.Mol.Biol.