CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cytochrome P450 302a1, mitochondrial |
Enzyme Information
| 1.14.15.16 |
Vitamin D(3) 24-hydroxylase.
based on mapping to UniProt Q09128
(1) Calcitriol + 2 reduced adrenodoxin + 2 H(+) + O(2) = calcitetrol + 2 oxidized adrenodoxin + H(2)O. (2) Calcidiol + 2 reduced adrenodoxin + 2 H(+) + O(2) = secalciferol + 2 oxidized adrenodoxin + H(2)O.
-!- The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. -!- The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D(3)-26,23-lactone as end product while the mouse and rat enzymes do not. -!- The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6. -!- Formerly EC 1.14.13.126 and EC 1.14.13.n4.
|
UniProtKB Entries (1)
| Q09128 |
CP24A_RAT
Rattus norvegicus
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
|
PDB Structure
| PDB | 3K9V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.
J.Mol.Biol.
|
