CATH Domain 3iifC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.220	Leucine Aminopeptidase, subunit E; domain 1
	3.40.220.10	Leucine Aminopeptidase, subunit E, domain 1

Domain Context

CATH Clusters

Superfamily	Leucine Aminopeptidase, subunit E, domain 1
Functional Family	Core histone macro-H2A

Enzyme Information

UniProtKB Entries (1)

H2AY_HUMAN

Homo sapiens

Core histone macro-H2A.1

PDB Structure

PDB	3IIF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Timinszky, G., Till, S., Hassa, P.O., Hothorn, M., Kustatscher, G., Nijmeijer, B., Colombelli, J., Altmeyer, M., Stelzer, E.H., Scheffzek, K., Hottiger, M.O., Ladurner, A.G. Nat.Struct.Mol.Biol.