CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.200 | Tumour Suppressor Smad4 |
|
2.60.200.20 |
Domain Context
CATH Clusters
| Superfamily | 2.60.200.20 |
| Functional Family | Serine/threonine-protein kinase Chk2 |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O96017
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
UniProtKB Entries (1)
| O96017 |
CHK2_HUMAN
Homo sapiens
Serine/threonine-protein kinase Chk2
|
PDB Structure
| PDB | 3I6W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.
Mol.Cell
|