CATH Domain 3i5nA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	3I5N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors Boezio, A.A., Berry, L., Albrecht, B.K., Bauer, D., Bellon, S.F., Bode, C., Chen, A., Choquette, D., Dussault, I., Hirai, S., Kaplan-Lefko, P., Larrow, J.F., Lin, M.H., Lohman, J., Potashman, M.H., Rex, K., Santostefano, M., Shah, K., Shimanovich, R., Springer, S.K., Teffera, Y., Yang, Y., Zhang, Y., Harmange, J.C. Bioorg.Med.Chem.Lett.