CATH Domain 3hwkH01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.580	Citrate Synthase; domain 1
	1.10.580.10	Citrate Synthase, domain 1

Domain Context

CATH Clusters

Superfamily	Citrate Synthase, domain 1
Functional Family	Citrate synthase

Enzyme Information

2.3.3.5

2-methylcitrate synthase.

based on mapping to UniProt I6Y9Q3

Propanoyl-CoA + H(2)O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3- tricarboxylate + CoA.

-!- The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. -!- The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1. -!- Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate. -!- Formerly EC 4.1.3.31.

2.3.3.16

Citrate synthase (unknown stereospecificity).

based on mapping to UniProt I6Y9Q3

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.

-!- This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C(2) of oxaloacetate has not been established (cf. EC 2.3.3.1 and EC 2.3.3.3).

UniProtKB Entries (1)

I6Y9Q3

PRPC_MYCTU

Mycobacterium tuberculosis H37Rv

2-methylcitrate synthase

PDB Structure

PDB	3HWK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Increasing the structural coverage of tuberculosis drug targets. Baugh, L., Phan, I., Begley, D.W., Clifton, M.C., Armour, B., Dranow, D.M., Taylor, B.M., Muruthi, M.M., Abendroth, J., Fairman, J.W., Fox, D., Dieterich, S.H., Staker, B.L., Gardberg, A.S., Choi, R., Hewitt, S.N., Napuli, A.J., Myers, J., Barrett, L.K., Zhang, Y., Ferrell, M., Mundt, E., Thompkins, K., Tran, N., Lyons-Abbott, S., Abramov, A., Sekar, A., Serbzhinskiy, D., Lorimer, D., Buchko, G.W., Stacy, R., Stewart, L.J., Edwards, T.E., Van Voorhis, W.C., Myler, P.J. Tuberculosis (Edinb)