CATH Domain 3fw3A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.200	Carbonic Anhydrase II
	3.10.200.10	Alpha carbonic anhydrase

Domain Context

CATH Clusters

Superfamily	Alpha carbonic anhydrase
Functional Family	Carbonic anhydrase 12

Enzyme Information

4.2.1.1

Carbonic anhydrase.

based on mapping to UniProt P22748

H(2)CO(3) = CO(2) + H(2)O.

-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P22748

CAH4_HUMAN

Homo sapiens

Carbonic anhydrase 4

PDB Structure

PDB	3FW3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation. Vernier, W., Chong, W., Rewolinski, D., Greasley, S., Pauly, T., Shaw, M., Dinh, D., Ferre, R.A., Nukui, S., Ornelas, M., Reyner, E. Bioorg.Med.Chem.