CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1580 | Nucleoside phosphorylase domain |
Domain Context
CATH Clusters
| Superfamily | Nucleoside phosphorylase domain |
| Functional Family | Uridine phosphorylase 2 |
Enzyme Information
| 2.4.2.3 |
Uridine phosphorylase.
based on mapping to UniProt Q16831
Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
-!- The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. -!- The mammalian enzyme also accepts 2'-deoxyuridine. -!- Formerly EC 2.4.2.23.
|
UniProtKB Entries (1)
| Q16831 |
UPP1_HUMAN
Homo sapiens
Uridine phosphorylase 1
|
PDB Structure
| PDB | 3EUE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy.
Bmc Struct.Biol.
|
