CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.25 | Alpha Horseshoe |
|
1.25.40 | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
|
1.25.40.120 | Protein prenylyltransferase |
Domain Context
CATH Clusters
| Superfamily | Protein prenylyltransferase |
| Functional Family | Geranylgeranyl transferase type-2 subunit alpha |
Enzyme Information
| 2.5.1.60 |
Protein geranylgeranyltransferase type II.
based on mapping to UniProt Q08602
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.
-!- This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes. -!- Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs. -!- Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). -!- Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.
|
UniProtKB Entries (1)
| Q08602 |
PGTA_RAT
Rattus norvegicus
Geranylgeranyl transferase type-2 subunit alpha
|
PDB Structure
| PDB | 3DSV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
Embo J.
|