CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.70 | Cathepsin D, subunit A; domain 1 |
|
2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
| Superfamily | Acid Proteases |
| Functional Family | Pepsin A |
Enzyme Information
| 3.4.23.4 |
Chymosin.
based on mapping to UniProt P00794
Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single 104-Ser-Phe-|-Met-Ala-107 bond in kappa-chain of casein.
-!- Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. -!- Found among mammals with postnatal uptake of immunoglobins. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.3.
|
UniProtKB Entries (1)
| P00794 |
CHYM_BOVIN
Bos taurus
Chymosin
|
PDB Structure
| PDB | 3CMS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Engineering enzyme subsite specificity: preparation, kinetic characterization, and X-ray analysis at 2.0-A resolution of Val111Phe site-mutated calf chymosin.
Biochemistry
|
