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1 keywords

CATH Domain 3c6mD03

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.50 Rossmann fold
Homologous Superfamily 3.40.50.150 Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family spermine synthase

Enzyme Information

2.5.1.22
Spermine synthase.
based on mapping to UniProt P52788
S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl- 5'-thioadenosine + spermine.
-!- The enzyme from mammalia is highly specific for spermidine, cf. EC 2.5.1.16 and EC 2.5.1.23.

UniProtKB Entries (1)

P52788
SPSY_HUMAN
Homo sapiens
Spermine synthase

PDB Structure

PDB 3C6M
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
Wu, H., Min, J., Zeng, H., McCloskey, D.E., Ikeguchi, Y., Loppnau, P., Michael, A.J., Pegg, A.E., Plotnikov, A.N.
J.Biol.Chem.
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