CATH Domain 3bzuC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt P28845

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_HUMAN

Homo sapiens

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	3BZU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor. Hale, C., Veniant, M., Wang, Z., Chen, M., McCormick, J., Cupples, R., Hickman, D., Min, X., Sudom, A., Xu, H., Matsumoto, G., Fotsch, C., St Jean, D.J., Wang, M. Chem.Biol.Drug Des.