CATH Domain 3bt7B01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	tRNA/tmRNA (uracil-C(5))-methyltransferase

Enzyme Information

2.1.1.35	tRNA (uracil(54)-C(5))-methyltransferase. based on mapping to UniProt P23003 S-adenosyl-L-methionine + uracil(54) in tRNA = S-adenosyl-L-homocysteine + 5-methyluracil(54) in tRNA. -!- Unlike this enzyme, EC 2.1.1.74 uses 5,10-methylenetetrahydrofolate and FADH(2) to supply the atoms for methylation of U54.
2.1.1.-	Methyltransferases. based on mapping to UniProt P23003

UniProtKB Entries (1)

TRMA_ECOLI

Escherichia coli K-12

TRNA/tmRNA (uracil-C(5))-methyltransferase

PDB Structure

PDB	3BT7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. Alian, A., Lee, T.T., Griner, S.L., Stroud, R.M., Finer-Moore, J. Proc.Natl.Acad.Sci.Usa