CATH Domain 3bt2A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.20	Plasminogen Kringle 4
	2.40.20.10	Plasminogen Kringle 4

Domain Context

CATH Clusters

Superfamily	Plasminogen Kringle 4
Functional Family	Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73

U-plasminogen activator.

based on mapping to UniProt P00749

Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P04004

VTNC_HUMAN

Homo sapiens

Vitronectin

PDB Structure

PDB	3BT2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes Huai, Q., Zhou, A., Lin, L., Mazar, A.P., Parry, G.C., Callahan, J., Shaw, D.E., Furie, B., Furie, B.C., Huang, M. Nat.Struct.Mol.Biol.