CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.110 | 4 Propeller |
|
2.110.10 | Hemopexin |
|
2.110.10.10 | Hemopexin-like domain |
Domain Context
CATH Clusters
| Superfamily | Hemopexin-like domain |
| Functional Family | Matrix metallopeptidase 3 |
Enzyme Information
| 3.4.24.65 |
Macrophage elastase.
based on mapping to UniProt P39900
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
-!- Belongs to peptidase family M10B.
|
UniProtKB Entries (1)
| P39900 |
MMP12_HUMAN
Homo sapiens
Macrophage metalloelastase
|
PDB Structure
| PDB | 3BA0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12.
J.Am.Chem.Soc.
|