CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.180 | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 |
|
3.10.180.10 | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 |
| Functional Family | 2,3-dihydroxybiphenyl 1,2-dioxygenase |
Enzyme Information
| 1.13.11.25 |
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5- dioxygenase.
based on mapping to UniProt P9WNW7
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate.
-!- Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.
|
UniProtKB Entries (1)
| P9WNW7 |
HSAC_MYCTU
Mycobacterium tuberculosis H37Rv
Iron-dependent extradiol dioxygenase
|
PDB Structure
| PDB | 2ZYQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
Plos Pathog.
|
