CATH Domain 2zv2A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Calcium/calmodulin-dependent protein kinase kinase 2 isoform 1

Enzyme Information

2.7.11.17

Calcium/calmodulin-dependent protein kinase.

based on mapping to UniProt Q96RR4

ATP + a protein = ADP + a phosphoprotein.

-!- Requires calmodulin. -!- A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein. -!- Not identical with EC 2.7.11.18 or EC 2.7.11.26. -!- Formerly EC 2.7.1.120 and EC 2.7.1.123.

UniProtKB Entries (1)

Q96RR4

KKCC2_HUMAN

Homo sapiens

Calcium/calmodulin-dependent protein kinase kinase 2

PDB Structure

PDB	2ZV2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609 Kukimoto-Niino, M., Yoshikawa, S., Takagi, T., Ohsawa, N., Tomabechi, Y., Terada, T., Shirouzu, M., Suzuki, A., Lee, S., Yamauchi, T., Okada-Iwabu, M., Iwabu, M., Kadowaki, T., Minokoshi, Y., Yokoyama, S. J.Biol.Chem.

Network disruptions