CATH Domain 2zu6A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Eukaryotic initiation factor 4A-III

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt P60842

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q53EL6

PDCD4_HUMAN

Homo sapiens

Programmed cell death protein 4

PDB Structure

PDB	2ZU6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the eIF4A-PDCD4 complex Chang, J.H., Cho, Y.H., Sohn, S.Y., Choi, J.M., Kim, A., Kim, Y.C., Jang, S.K., Cho, Y. Proc.Natl.Acad.Sci.Usa