CATH Domain 2zn7A00

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	Tyrosine-protein phosphatase non-receptor type 1

3.1.3.48

Protein-tyrosine-phosphatase.

based on mapping to UniProt P18031

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

PTN1_HUMAN

Homo sapiens

Tyrosine-protein phosphatase non-receptor type 1

PDB	2ZN7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24 Wan, Z.-K., Lee, J., Hotchandani, R., Moretto, A., Binnun, E., Wilson, D.P., Kirincich, S.J., Follows, B.C., Ipek, M., Xu, W., Joseph-McCarthy, D., Zhang, Y.-L., Tam, M., Erbe, D.V., Tobin, J.F., Li, W., Tam, S.Y., Mansour, T.S., Wu, J. Chemmedchem