CATH Domain 2yf0A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Domain Context

CATH Clusters

Superfamily	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family	Myotubularin related protein 6

Enzyme Information

3.1.3.64	Phosphatidylinositol-3-phosphatase. based on mapping to UniProt Q9Y217 1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol + phosphate. -!- This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyzes Ins(1,3)P(2) to Ins-1-P. -!- Formerly EC 3.1.3.65.
3.1.3.95	Phosphatidylinositol-3,5-bisphosphate 3-phosphatase. based on mapping to UniProt Q9Y217 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 5-phosphate + phosphate. -!- The enzyme is found in both plants and animals. -!- It also has the activity of EC 3.1.3.64.

UniProtKB Entries (1)

MTMR6_HUMAN

Homo sapiens

Myotubularin-related protein 6

PDB Structure

PDB	2YF0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Human Mtmr6 Moche, M., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Kouznetsova, E., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., Vandenberg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P. To be Published