CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.650 | Cupin |
Domain Context
CATH Clusters
| Superfamily | Cupin |
| Functional Family | Lysine-specific demethylase 4A |
Enzyme Information
| 1.14.11.- |
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt O75164
|
UniProtKB Entries (1)
| Q16695 |
H31T_HUMAN
Homo sapiens
Histone H3.1t
|
PDB Structure
| PDB | 2YBP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
EMBO Rep.
|