CATH Domain 2vxoA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.620	HUPs

Domain Context

CATH Clusters

Superfamily	HUPs
Functional Family	GMP synthase [glutamine-hydrolyzing]

Enzyme Information

6.3.5.2

GMP synthase (glutamine-hydrolyzing).

based on mapping to UniProt P49915

ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.

-!- Involved in the de novo biosynthesis of guanosine nucleotides. -!- An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. -!- The enzyme can catalyze the second reaction alone in the presence of ammonia. -!- Formerly EC 6.3.4.1.

UniProtKB Entries (1)

P49915

GUAA_HUMAN

Homo sapiens

GMP synthase [glutamine-hydrolyzing]

PDB Structure

PDB	2VXO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Substrate Specificity and Oligomerization of Human Gmp Synthetase Welin, M., Lehtio, L., Johansson, A., Flodin, S., Nyman, T., Tresaugues, L., Hammarstrom, M., Graslund, S., Nordlund, P. J.Mol.Biol.