CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.29 | PH-domain like |
|
2.30.29.30 | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
Domain Context
CATH Clusters
| Superfamily | Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) |
| Functional Family | Rho guanine nucleotide exchange factor (GEF) 25 |
Enzyme Information
UniProtKB Entries (2)
| P21279 |
GNAQ_MOUSE
Mus musculus
Guanine nucleotide-binding protein G(q) subunit alpha
|
| Q86VW2 |
ARHGP_HUMAN
Homo sapiens
Rho guanine nucleotide exchange factor 25
|
PDB Structure
| PDB | 2RGN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Trichoplusia |
| Primary Citation |
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Science
|
