CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1520 | PX Domain |
|
3.30.1520.10 | Phox-like domain |
Domain Context
CATH Clusters
| Superfamily | Phox-like domain |
| Functional Family | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha |
Enzyme Information
| 2.7.1.154 |
Phosphatidylinositol-4-phosphate 3-kinase.
based on mapping to UniProt O00443
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate.
-!- This enzyme also phosphorylates PtdIns to PtdIns3P.
|
UniProtKB Entries (1)
| O00443 |
P3C2A_HUMAN
Homo sapiens
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
|
PDB Structure
| PDB | 2REA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding
Bmc Struct.Biol.
|
