CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.510 | Transferase(Phosphotransferase); domain 1 |
|
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
| Superfamily | Transferase(Phosphotransferase) domain 1 |
| Functional Family | Serine/threonine-protein kinase receptor |
Enzyme Information
| 2.7.11.30 |
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q13705
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| Q13705 |
AVR2B_HUMAN
Homo sapiens
Activin receptor type-2B
|
PDB Structure
| PDB | 2QLU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution
Protein Sci.
|