CATH Domain 2ogzB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5

Dipeptidyl-peptidase IV.

based on mapping to UniProt P27487

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487

DPP4_HUMAN

Homo sapiens

Dipeptidyl peptidase 4

PDB Structure

PDB	2OGZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site. Sheehan, S.M., Mest, H.J., Watson, B.M., Klimkowski, V.J., Timm, D.E., Cauvin, A., Parsons, S.H., Shi, Q., Canada, E.J., Wiley, M.R., Ruehter, G., Evers, B., Petersen, S., Blaszczak, L.C., Pulley, S.R., Margolis, B.J., Wishart, G.N., Renson, B., Hankotius, D., Mohr, M., Zechel, J.C., Michael Kalbfleisch, J., Dingess-Hammond, E.A., Boelke, A., Weichert, A.G. Bioorg.Med.Chem.Lett.