CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.505 | SHC Adaptor Protein |
|
3.30.505.10 | SH2 domain |
Domain Context
CATH Clusters
| Superfamily | SH2 domain |
| Functional Family | phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 |
Enzyme Information
| 3.1.3.86 |
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
based on mapping to UniProt O15357
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.
-!- This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. -!- The enzyme also shows activity toward PtdIns(1,3,4,5)P(4). -!- The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. -!- Formerly EC 3.1.3.n1.
|
UniProtKB Entries (1)
| O15357 |
SHIP2_HUMAN
Homo sapiens
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
|
PDB Structure
| PDB | 2MK2 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A.
To be Published
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