CATH Domain 2m6tA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.70	Distorted Sandwich
	2.70.130	Cation-dependent Mannose-6-phosphate Receptor; Chain A
	2.70.130.10	Mannose-6-phosphate receptor binding domain

Domain Context

CATH Clusters

Superfamily	Mannose-6-phosphate receptor binding domain
Functional Family	Insulin-like growth factor 2 receptor

Enzyme Information

UniProtKB Entries (1)

MPRI_HUMAN

Homo sapiens

Cation-independent mannose-6-phosphate receptor

PDB Structure

PDB	2M6T
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Frago, S., Nicholls, R.D., Strickland, M., Hughes, J., Williams, C., Garner, L., Surakhy, M., Maclean, R., Rezgui, D., Prince, S.N., Zaccheo, O.J., Ebner, D., Sanegre, S., Yu, S., Buffa, F.M., Crump, M.P., Hassan, A.B. Proc.Natl.Acad.Sci.USA