CATH Domain 2kmuA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.1460

Domain Context

CATH Clusters

Superfamily	1.10.10.1460
Functional Family	DNA replication regulator Sld2

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt O94761

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

O94761

RECQ4_HUMAN

Homo sapiens

ATP-dependent DNA helicase Q4

PDB Structure

PDB	2KMU
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif Ohlenschlager, O., Kuhnert, A., Schneider, A., Haumann, S., Bellstedt, P., Keller, H., Saluz, H.P., Hortschansky, P., Hanel, F., Grosse, F., Gorlach, M., Pospiech, H. Nucleic Acids Res.