CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.100
Functional Family copper-transporting ATPase 1

Enzyme Information

7.2.2.8
P-type Cu(+) transporter.
based on mapping to UniProt Q04656
ATP + H(2)O + Cu(+)(Side 1) = ADP + phosphate + Cu(+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC 7.2.2.9, which mainly transports the divalent copper ion. -!- Formerly EC 3.6.3.54.

UniProtKB Entries (1)

Q04656
ATP7A_HUMAN
Homo sapiens
Copper-transporting ATPase 1

PDB Structure

PDB 2K1R
External Links
Method SOLUTION NMR
Organism
Primary Citation
The solution structure of the copper(I)-mediated complex between the first soluble domain of the Menkes protein and the metallochaperone HAH1.
Bertini, I., Banci, L.C., Felli, I.C., Pavelkova, A., Rosato, A.
To be Published
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