CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.11610 | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain |
| Functional Family | 2-oxoglutarate dehydrogenase E1 component |
Enzyme Information
| 1.2.4.2 |
Oxoglutarate dehydrogenase (succinyl-transferring).
based on mapping to UniProt P0AFG3
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
-!- It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61, which also binds multiple copies of EC 1.8.1.4. -!- It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.61.
|
UniProtKB Entries (1)
| P0AFG3 |
ODO1_ECOLI
Escherichia coli K-12
2-oxoglutarate dehydrogenase E1 component
|
PDB Structure
| PDB | 2JGD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of the E1 Component of the Escherichia Coli 2-Oxoglutarate Dehydrogenase Multienzyme Complex.
J.Mol.Biol.
|