CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.550.50
Functional Family Beta-1,3-N-acetylglucosaminyltransferase

Enzyme Information

2.4.1.222
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
based on mapping to UniProt O09008
Transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor.
-!- O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferases are the products of fringe genes. -!- O-linked fucose is an unusual form of glycosylation where the fucose is attached directly to proteins through the hydroxy groups of Ser or Thr residues.

UniProtKB Entries (1)

O09008
MFNG_MOUSE
Mus musculus
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

PDB Structure

PDB 2J0A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
Nat.Struct.Mol.Biol.