CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | ketimine reductase mu-crystallin |
Enzyme Information
| 1.5.1.25 |
Thiomorpholine-carboxylate dehydrogenase.
based on mapping to UniProt Q14894
Thiomorpholine 3-carboxylate + NAD(P)(+) = 3,4-dehydro-thiomorpholine-3- carboxylate + NAD(P)H.
-!- The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. -!- In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, more slowly.
|
UniProtKB Entries (1)
| Q14894 |
CRYM_HUMAN
Homo sapiens
Ketimine reductase mu-crystallin
|
PDB Structure
| PDB | 2I99 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of human {micro}-crystallin complexed with NADPH
Protein Sci.
|
