CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.410 | von Willebrand factor, type A domain |
Domain Context
CATH Clusters
| Superfamily | von Willebrand factor, type A domain |
| Functional Family | Complement C2 |
Enzyme Information
| 3.4.21.43 |
Classical-complement-pathway C3/C5 convertase.
based on mapping to UniProt P06681
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha- chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
-!- A complex of complement fragments C4b, C2a and C2b. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.44.
|
UniProtKB Entries (1)
| P06681 |
CO2_HUMAN
Homo sapiens
Complement C2
|
PDB Structure
| PDB | 2I6S |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Mesocricetus |
| Primary Citation |
Structure of complement component c2a: implications for convertase formation and substrate binding.
Structure
|