CATH Domain 2gy5A03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.300	Tie2 ligand-binding domain fold
	2.170.300.10	Tie2 ligand-binding domain superfamily

Domain Context

CATH Clusters

Superfamily	Tie2 ligand-binding domain superfamily
Functional Family

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt Q02763

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q02763

TIE2_HUMAN

Homo sapiens

Angiopoietin-1 receptor

PDB Structure

PDB	2GY5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex. Barton, W.A., Tzvetkova-Robev, D., Miranda, E.P., Kolev, M.V., Rajashankar, K.R., Himanen, J.P., Nikolov, D.B. Nat.Struct.Mol.Biol.