CATH Domain 2gv9B06

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.132	Topoisomerase I; Chain A, domain 4
	1.10.132.60	DNA polymerase family B, C-terminal domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase family B, C-terminal domain
Functional Family	DNA polymerase catalytic subunit

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P04292 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.26.4	Ribonuclease H. based on mapping to UniProt P04292 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.

UniProtKB Entries (1)

DPOL_HHV1K

Human alphaherpesvirus 1 strain KOS

DNA polymerase catalytic subunit

PDB Structure

PDB	2GV9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Crystal structure of the herpes simplex virus 1 DNA polymerase. Liu, S., Knafels, J.D., Chang, J.S., Waszak, G.A., Baldwin, E.T., Deibel, M.R., Thomsen, D.R., Homa, F.L., Wells, P.A., Tory, M.C., Poorman, R.A., Gao, H., Qiu, X., Seddon, A.P. J.Biol.Chem.