CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.430 | Dihydrofolate Reductase, subunit A |
|
3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
| Superfamily | Dihydrofolate Reductase, subunit A |
| Functional Family |
Enzyme Information
| 1.1.1.302 |
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase.
based on mapping to UniProt Q58085
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)(+) = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H.
-!- The reaction proceeds in the opposite direction. -!- A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. -!- Differs from EC 1.1.1.193 since it does not catalyze the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate.
|
UniProtKB Entries (1)
| Q58085 |
RIB7_METJA
Methanocaldococcus jannaschii DSM 2661
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
|
PDB Structure
| PDB | 2AZN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii
J.Mol.Biol.
|
