CATH Domain 1ymnA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.130	P-30 Protein
	3.10.130.10	Ribonuclease A-like domain

Domain Context

CATH Clusters

Superfamily	Ribonuclease A-like domain
Functional Family	Ribonuclease pancreatic

Enzyme Information

4.6.1.18

Pancreatic ribonuclease.

based on mapping to UniProt P61823

(1) An (RNA) containing cytidine + H(2)O = an (RNA)-3'-cytidine- 3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA). (2) An (RNA) containing uridine + H(2)O = an (RNA)-3'-uridine- 3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).

-!- Specifically cleaves at the 3'-side of pyrimidine (uracil or cytosine) phosphate bonds in RNA. -!- The reaction takes place in two steps, with the 2',3'-cyclic phosphodiester intermediates released from the enzyme at the completion of the first step. -!- Hydrolysis of these cyclic compounds occurs at a much slower rate through a reversal of the first step, in which the -OH group of water substitutes for the 2'-OH group of the ribose used in the first step, and does not take place until essentially all the susceptible 3',5'-phosphodiester bonds have been cyclised. -!- The enzyme can act as an endo- or exo ribonuclease. -!- Formerly EC 2.7.7.16, EC 3.1.4.22 and EC 3.1.27.5.

UniProtKB Entries (1)

P61823

RNAS1_BOVIN

Bos taurus

Ribonuclease pancreatic

PDB Structure

PDB	1YMN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	A localized specific interaction alters the unfolding pathways of structural homologues. Xu, G., Narayan, M., Kurinov, I., Ripoll, D.R., Welker, E., Khalili, M., Ealick, S.E., Scheraga, H.A. J.Am.Chem.Soc.