CATH Domain 1t32A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Complement factor D

Enzyme Information

3.4.21.20

Cathepsin G.

based on mapping to UniProt P08311

Specificity similar to chymotrypsin C.

-!- From azurophil granules of polymorphonuclear leukocytes. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

CATG_HUMAN

Homo sapiens

Cathepsin G

PDB Structure

PDB	1T32
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. de Garavilla, L., Greco, M.N., Sukumar, N., Chen, Z.W., Pineda, A.O., Mathews, F.S., Di Cera, E., Giardino, E.C., Wells, G.I., Haertlein, B.J., Kauffman, J.A., Corcoran, T.W., Derian, C.K., Eckardt, A.J., Damiano, B.P., Andrade-Gordon, P., Maryanoff, B.E. J.Biol.Chem.