CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.70 | Cathepsin B; Chain A |
|
3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
| Superfamily | Cysteine proteinases |
| Functional Family | Papain |
Enzyme Information
| 3.4.22.2 |
Papain.
based on mapping to UniProt P00784
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.
-!- From latex of the papaya (Carica papaya). -!- Inhibited by compound E-64 and proteins of the cystatin family. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.10.
|
UniProtKB Entries (2)
| P00784 |
PAPA1_CARPA
Carica papaya
Papain
|
| P04080 |
CYTB_HUMAN
Homo sapiens
Cystatin-B
|
PDB Structure
| PDB | 1STF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.
EMBO J.
|
