CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.230 | Ribosomal Protein S5; domain 2 |
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3.30.230.10 |
Domain Context
CATH Clusters
Superfamily | 3.30.230.10 |
Functional Family | DNA topoisomerase 4 subunit B |
Enzyme Information
5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P20083
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
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UniProtKB Entries (1)
P20083 |
PARE_ECOLI
Escherichia coli K-12
DNA topoisomerase 4 subunit B
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PDB Structure
PDB | 1S16 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother.
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