CATH Domain 1qsvA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Vascular endothelial growth factor receptor 1

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P17948

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P17948

VGFR1_HUMAN

Homo sapiens

Vascular endothelial growth factor receptor 1

PDB Structure

PDB	1QSV
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism	Escherichia
Primary Citation	Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. Starovasnik, M.A., Christinger, H.W., Wiesmann, C., Champe, M.A., de Vos, A.M., Skelton, N.J. J.Mol.Biol.