CATH Classification

Domain Context

CATH Clusters

Superfamily Plasminogen Kringle 4
Functional Family Urokinase-type plasminogen activator

Enzyme Information

3.4.21.68
T-plasminogen activator.
based on mapping to UniProt P00750
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00750
TPA_HUMAN
Homo sapiens
Tissue-type plasminogen activator

PDB Structure

PDB 1PK2
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.
Byeon, I.J., Llinas, M.
J.Mol.Biol.