CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.70 | Cathepsin D, subunit A; domain 1 |
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2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
Superfamily | Acid Proteases |
Functional Family | Plasmepsin-2 |
Enzyme Information
3.4.23.39 |
Plasmepsin II.
based on mapping to UniProt P46925
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-|-Phe(NO(2))-Ser-Phe-Pro-Thr.
-!- Inhibited by pepstatin. -!- Belongs to peptidase family A1.
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UniProtKB Entries (1)
P46925 |
PLM2_PLAFA
Plasmodium falciparum
Plasmepsin-2
|
PDB Structure
PDB | 1PFZ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.
Nat.Struct.Biol.
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