CATH Classification

Domain Context

CATH Clusters

Superfamily 2.80.10.50
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt Q6ITZ3
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

Q6ITZ3
ML4_VISAL
Viscum album
Beta-galactoside-specific lectin 4

PDB Structure

PDB 1PC8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a novel ribosome-inactivating protein from a hemi-parasitic plant inhabiting the northwestern Himalayas.
Mishra, V., Ethayathulla, A.S., Sharma, R.S., Yadav, S., Krauspenhaar, R., Betzel, C., Babu, C.R., Singh, T.P.
Acta Crystallogr.,Sect.D
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