CATH Domain 1p9pA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1270	Trp Operon Repressor; Chain A
	1.10.1270.20	tRNA(m1g37)methyltransferase, domain 2

Domain Context

CATH Clusters

Superfamily	tRNA(m1g37)methyltransferase, domain 2
Functional Family	tRNA (guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228

tRNA (guanine(37)-N(1))-methyltransferase.

based on mapping to UniProt P0A873

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.

-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

P0A873

TRMD_ECOLI

Escherichia coli K-12

TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB	1P9P
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Insights into Catalysis by a Knotted TrmD tRNA Methyltransferase. Elkins, P.A., Watts, J.M., Zalacain, M., Van Thiel, A., Vitaszka, P.R., Redlak, M., Andraos-Selim, C., Rastinejad, F., Holmes, W.M. J.Mol.Biol.