CATH Domain 1p9pA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1280	Alpha/beta knot
	3.40.1280.10	SPOUT methyltransferase, trefoil knot domain

Domain Context

CATH Clusters

Superfamily	3.40.1280.10
Functional Family	tRNA (guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228

tRNA (guanine(37)-N(1))-methyltransferase.

based on mapping to UniProt P0A873

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.

-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

P0A873

TRMD_ECOLI

Escherichia coli K-12

TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB	1P9P
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Insights into Catalysis by a Knotted TrmD tRNA Methyltransferase. Elkins, P.A., Watts, J.M., Zalacain, M., Van Thiel, A., Vitaszka, P.R., Redlak, M., Andraos-Selim, C., Rastinejad, F., Holmes, W.M. J.Mol.Biol.