CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.575 | P1 Nuclease |
|
1.10.575.10 | P1 Nuclease |
Domain Context
CATH Clusters
| Superfamily | P1 Nuclease |
| Functional Family | Phospholipase C |
Enzyme Information
| 3.1.4.3 |
Phospholipase C.
based on mapping to UniProt P09598
A phosphatidylcholine + H(2)O = 1,2-diacyl-sn-glycerol + phosphocholine.
-!- The bacterial enzyme also acts on sphingomyelin and phosphatidylinositol. -!- The enzyme from seminal plasma does not act on phosphatidylinositol.
|
UniProtKB Entries (1)
| P09598 |
PHLC_BACCE
Bacillus cereus
Phospholipase C
|
PDB Structure
| PDB | 1P5X |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Using X-ray crystallography of the Asp55Asn mutant of the phosphatidylcholine-preferring phospholipase C from Bacillus cereus to support the mechanistic role of Asp55 as the general base.
Arch.Biochem.Biophys.
|